The Complete Rohto Eye Drops Guide: How to Choose the Right Drop for Your Eyes

TsujimotoNatalia
2026-03-31T12:30:06+09:00

Why Rohto Is Japan's Most Trusted Eye Drop Brand

I've been living in Japan since 2002, and Rohto eye drops are something I have always kept in my bathroom cabinet. Walk into any Japanese pharmacy and you'll find an entire wall dedicated to eye drops — dozens of boxes, all looking similar, with names like Z!, Gold 40, Digi-Eye, and C Cube. For a first-time buyer, it's completely overwhelming. For me, after years of sourcing these products for Tsujimoto Market, it has become second nature.

This guide covers the complete Rohto lineup we carry — explaining what each product does, who it's for, and how the various series differ from one another. By the end, you'll know exactly which bottle to reach for.

Understanding the Rohto Freshness Scale

Before diving into individual products, it helps to understand one concept that defines the entire Rohto range: the freshness scale. Rohto rates every product from 0 (no cooling sensation at all) to 8+ (maximum intensity — a sharp, icy shock that pierces through to the back of the eye). This scale is the single most useful piece of information when choosing between products.

The cooling sensation comes from combinations of l-Menthol, d-Camphor, and d-Borneol. More agents, higher concentrations = higher freshness level. A higher number is not always better — it depends entirely on your personal preference and sensitivity. Here's a quick overview of where the main products sit:

Level 0 — Rohto C Cube a, Rohto Gold 40 Mild (no menthol, no sensation at all)

Level 3 — Rohto Digi-Eye a (mild cooling)

Level 4 — Rohto Gold 40 Cool, Rohto Digi-Eye Contact (moderate)

Level 5 — Rohto C Cube Cool a, Rohto Cool 40A (noticeably refreshing)

Level 6 — Rohto Vita 40A (strong)

Level 7 — Rohto C Cube Ice Cool a (intensely cold)

Level 8+ — Rohto Z!, Rohto Z! Pro, Rohto Z Contact b (maximum, the famous Rohto sensation)

No Contact Lenses? Start with the Z! and 40 Series

If you don't wear contact lenses and want the classic Rohto experience — immediate, powerful refreshment — the Z! and 40 series are where to begin.

Rohto Z! and Rohto Z! Pro — The Iconic Maximum Cool

Rohto Z! is arguably the most famous eye drop in Japan. Freshness level 8+. The triple cooling combination of l-Menthol, d-Camphor, and d-Borneol creates an icy surge the moment the drop hits your eye — a sensation unlike anything in Western pharmacy. It relieves redness, itching, and eye fatigue quickly, and the effect lingers. It has become something of a rite of passage for visitors to Japan.

Rohto Z! Pro takes the same level-8+ cooling intensity and adds six active ingredients — including Neostigmine for ciliary muscle recovery and Vitamin B6 for nerve support. This makes it the better choice if fatigue, blurred vision, or prolonged screen use is your concern alongside the cooling you love. Both Z! and Z! Pro are for bare eyes only — they cannot be used with soft contact lenses.

Rohto Cool 40A and Rohto Vita 40A

For a step down in intensity with added nutritional support, Rohto Cool 40A (level 5) and Rohto Vita 40A (level 6) are excellent daily-use options. Both contain six active ingredients and are formulated to prevent blurred vision, relieve redness, and protect against UV and infection. Vita 40A adds Vitamin E for antioxidant protection. Neither can be used with soft contact lenses.

Eye Nutrition and Age-Related Vision Support

As we age, the eyes' ability to focus weakens, and the ciliary muscle — responsible for adjusting the lens — becomes less responsive. Rohto's nutrition-focused range addresses this directly.

Rohto Gold 40 Cool — Six Active Ingredients for Mature Eyes

Rohto Gold 40 Cool is specifically designed for eyes aged 40 and above. The "Gold" in the name reflects the concentration of six active ingredients — Neostigmine, Vitamin B6, Vitamin B12, Taurine, Potassium L-Aspartate, and Sodium Chondroitin Sulfate — all at the maximum concentrations permitted under Japanese OTC pharmaceutical law. At freshness level 4, it's noticeably refreshing without being overwhelming. It comes in a generous 20ml bottle — larger than most eye drops.

Rohto V Premium and Rohto V-CTIVE — Vitamin-Loaded Anti-Fatigue

Rohto V Premium is the flagship of the V series — twelve active ingredients, the largest number in the entire Rohto range. It addresses fatigue, blurred vision, redness, and dryness comprehensively. If you want the most nutritionally complete drop for tired eyes, this is it.

For lens wearers who need a nutritionally rich option, Rohto Premium Contact is the most comprehensive contact-lens-safe formula in the lineup — combining deep hydration with multi-active fatigue and damage repair for those who wear lenses for long hours daily.

Dry Eye Therapy: When Moisture Matters Most

Dry eye is one of the most common complaints among office workers, screen users, and contact lens wearers. Rohto's dry eye range goes well beyond standard lubricant drops.

Rohto Premium Dry Eye — The Most Nutritious Dry Eye Formula

Rohto Premium Dry Eye contains the richest formulation specifically designed for dry eye syndrome. It combines multiple active ingredients to both replenish the tear film and address the cellular damage that chronic dryness causes. For those who rely on lubricating drops daily, this is one of the most comprehensive Japanese pharmacy options available.

Rohto Dryaid — 60x the Viscosity for Severe Dryness

Rohto Dryaid takes a different approach to dry eye: instead of adding more active ingredients, it dramatically increases the viscosity of the formula — hydroxyethyl cellulose at 60 times the standard concentration. This creates a thick, long-lasting coating over the eye surface that keeps moisture locked in for an extended period. It is particularly effective for severe dry eye where standard drops don't provide lasting relief.

Rohto for Contact Lens Wearers: The Full Spectrum

Choosing eye drops for contact lens wear requires extra care. Many active ingredients — and most preservatives — are incompatible with soft lenses. Rohto has built an extensive contact-safe lineup to cover every preference, from zero cooling to maximum intensity.

Rohto Lycee Contact and Rohto Premium Contact

Rohto Lycee Contact is a gentle, moisturising drop designed for everyday comfort with all lens types. Its soft formula is particularly popular with colour and circle contact lens wearers, and the distinctive pink bottle has made it one of the most recognisable drops in Japan. Rohto Premium Contact raises the nutritional profile significantly — it's the richest contact-lens-compatible formula in the lineup, combining deep hydration with multi-active fatigue and damage repair for those who wear lenses for long hours daily.

The C Cube Series — Choose Your Cooling Level

The C Cube line is a beautifully simple concept: three products with identical active ingredients and an identical preservative-free, contact-safe base — differentiated only by cooling intensity. All are safe for every lens type including colour and circle contacts.

Rohto C Cube a (level 0) — completely menthol-free, no sensation. Ideal for sensitive eyes and those who dislike cooling drops. Preservative-free.

Rohto C Cube Cool a (level 5) — refreshingly cool, with l-Menthol. The midpoint for lens wearers who enjoy a mild cooling sensation.

Rohto C Cube Ice Cool a (level 7) — intense, icy cooling with l-Menthol and d-Camphor. The strongest cooling available in a preservative-free lens-compatible formula.

All three use mineral components (potassium chloride, sodium chloride, calcium chloride) and Taurine as active ingredients, with hyaluronic acid and Poloxamer as moisturising additives. The eco-friendly packaging — no outer leaflet, minimal labelling — is a nice touch.

Rohto Z Contact b — Maximum Cooling for Lens Wearers

If even level 7 isn't enough, Rohto Z Contact b delivers the full Z!-level 8+ experience in a contact-lens-safe formula. This is the most intense cooling drop available for lens wearers anywhere in the Rohto lineup. The triple cooling complex (l-Menthol, d-Camphor, d-Borneol) is identical to Z! itself — the only difference is the base formula, designed to be compatible with contact lenses. A free-angle nozzle makes application easy from any position.

Digital Screen Fatigue: The Newest Category

Eye drops specifically targeting digital device fatigue are a relatively recent development, and Rohto's Digi-Eye line addresses it more precisely than any general-purpose drop.

Rohto Digi-Eye a — For Bare Eyes at the Screen

Rohto Digi-Eye a has a distinctive purple colour — from Vitamin B12, one of its six active ingredients. Blue light from LED screens reduces blinking and strains the ciliary muscle. Digi-Eye a targets this directly: Vitamin B12 supports muscle recovery, Azulene Sodium Sulfonate soothes screen-induced conjunctival inflammation, and Sodium Chondroitin Sulfate forms a protective layer over the cornea. At freshness level 3, it offers mild refreshment. It cannot be used with soft contact lenses.

Rohto Digi-Eye Contact — Same Formula, Lens-Safe

If you wear contact lenses and spend your working day at a screen, Rohto Digi-Eye Contact was made for you. The formula combines screen-fatigue-specific active ingredients (Zinc Sulfate to reduce inflammation, Neostigmine for focusing muscle support, Vitamin E, Chondroitin, Taurine) with lens compatibility across all types. Sodium hyaluronate adds extra hydration. At level 4 cooling, it's noticeably refreshing without overwhelming sensitivity.

How to Choose: A Simple Decision Guide

With so many options, here's a quick framework for narrowing down your choice:

Do you wear soft contact lenses? — If yes, go to the contact-safe section: C Cube series, Z Contact b, Digi-Eye Contact, Lycee Contact, Premium Contact, or Dry Eye Contact.

Is your main problem dry eyes? — Rohto Dryaid (severe), Premium Dry Eye (nutritional support), or C Cube a (gentle daily use with lenses).

Is your main problem screen fatigue? — Digi-Eye a (no lenses) or Digi-Eye Contact (with lenses).

Are you over 40 and noticing blurred vision or slower focus? — Gold 40 Cool, V Premium, or the Rohto Premium range.

Do you just want that famous Z! cooling? — Z! or Z! Pro (without lenses), Z Contact b (with lenses).

Do you prefer no cooling sensation at all? — Rohto C Cube a (for contact lenses) and Rohto Gold 40 Mild (without lenses) are both at freshness level 0 — no menthol, no cooling whatsoever.

Frequently Asked Questions

Can I use any Rohto eye drop with contact lenses?

No. Rohto Z!, Z! Pro, Cool 40A, Vita 40A, Gold 40 Cool, and Digi-Eye a cannot be used with soft contact lenses. The products specifically designed for lens wear are: Lycee Contact, Premium Contact, Dry Eye Contact, the C Cube series (a / Cool a / Ice Cool a), Z Contact b, and Digi-Eye Contact.

Are Japanese Rohto eye drops different from the ones sold internationally?

Yes, significantly. Japanese domestic Rohto products are regulated as pharmaceutical drugs (OTC class 2 or 3), with strictly controlled active ingredient concentrations. The international versions sold in the US and Europe have different formulations and are typically classified as cosmetic products, with far fewer active ingredients. The Japanese versions are more potent and more precisely formulated.

How long does a bottle last after opening?

Most Rohto eye drop bottles should be used within 30 days of opening. The C Cube series (which is preservative-free) is particularly sensitive to contamination — keep the nozzle clean and the cap tightly closed after every use.

Which Rohto eye drop is best for redness?

Rohto Z! and Z! Pro both contain Naphazoline or Tetrahydrozoline — vasoconstrictors that reduce redness quickly. For lens wearers, Rohto Digi-Eye Contact contains Zinc Sulfate for inflammation and redness linked to screen use and lens wear.

Browse the Full Rohto Lineup

All the products mentioned in this guide are sourced directly from Japanese pharmacies and shipped to you from Kobe, Japan. Every bottle is authentic — no grey-market stock, no fakes. If you're unsure which product to choose after reading, feel free to reach out and I'll help you find the right match for your eyes.

Browse the complete Japanese Eye Drops collection at Tsujimoto Market to see the full range.