{"product_id":"pola-wrinkle-shot-medical-serum-n-20g","title":"POLA Wrinkle Shot Medical Serum N 20g | Japan's First MHLW-Approved Anti-Wrinkle Serum","description":"\u003ch2\u003ePOLA Wrinkle Shot Medical Serum N — Japan's First MHLW-Approved Anti-Wrinkle Serum\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003ePOLA Wrinkle Shot Medical Serum N\u003c\/strong\u003e is the renewed flagship of POLA's prestige anti-aging line. It is a quasi-drug (医薬部外品), meaning it carries Japan's Ministry of Health, Labour and Welfare (MHLW) authorization for the claim \"improves wrinkles\" — POLA was the first brand in Japan to receive this approval. The active ingredient \u003cstrong\u003eNEI-L1\u003c\/strong\u003e is a proprietary triple complex that targets the cellular processes behind deep wrinkles.\u003c\/p\u003e\n\u003cp\u003eThe serum has a rich, balm-like texture that melts into skin and is designed for spot-application on wrinkle-prone zones (forehead, eye corners, nasolabial folds, mouth corners). 20g lasts about 4 months with daily morning and evening use.\u003c\/p\u003e\n\n\u003ch3\u003eKey Benefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMHLW-approved wrinkle improvement\u003c\/strong\u003e — Japan's first quasi-drug serum certified to reduce visible wrinkles, not just hydrate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNEI-L1 active complex\u003c\/strong\u003e — POLA's proprietary triple ingredient targeting the wrinkle-formation pathway in the skin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentrated balm-melt texture\u003c\/strong\u003e — sits exactly where you place it, no migration into eyes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpot-application format\u003c\/strong\u003e — economical, focuses the active where you need it.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrestige Japanese authenticity\u003c\/strong\u003e — sourced directly from Japan, the renewed 2026 N formulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eUse morning and evening, after toner and serum, before moisturizer.\u003c\/li\u003e\n\u003cli\u003eDispense a rice-grain amount onto a fingertip.\u003c\/li\u003e\n\u003cli\u003eApply directly onto wrinkles (forehead lines, crow's feet, nasolabial folds, mouth corners). Do not rub into surrounding skin.\u003c\/li\u003e\n\u003cli\u003eContinue with your regular moisturizer or eye cream over the top.\u003c\/li\u003e\n\u003cli\u003eVisible change typically appears after 8–12 weeks of consistent use.\u003c\/li\u003e\n\u003c\/ol\u003e\n\n\u003ch3\u003eBest For\u003c\/h3\u003e\n\u003cp\u003eWomen in their late 30s through 60s who already use a moisturizer and want to specifically target visible wrinkles — crow's feet, frown lines, nasolabial folds, marionette lines. Pairs well with any base routine.\u003c\/p\u003e\n\n\u003ch3\u003eIngredients (highlights)\u003c\/h3\u003e\n\u003cp\u003eNEI-L1 (proprietary triple complex — primary wrinkle-improvement active), glycerin, dimethicone, ceramide-NP, niacinamide-supporting peptides. Refer to the package for the full INCI list. Free of mineral oil and synthetic fragrance.\u003c\/p\u003e\n\n\u003ch3\u003eCautions\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eFor external use only. Avoid direct contact with eyes — if the serum enters eyes, rinse immediately with water.\u003c\/li\u003e\n\u003cli\u003eApply a small amount first if you have sensitive skin and observe for 24 hours before regular use.\u003c\/li\u003e\n\u003cli\u003eDiscontinue use if redness, itching or stinging occurs.\u003c\/li\u003e\n\u003cli\u003eDo not use on broken, sunburnt or actively irritated skin.\u003c\/li\u003e\n\u003cli\u003eStore at room temperature, away from direct sunlight.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eShipping \u0026amp; Authenticity\u003c\/h3\u003e\n\u003cp\u003eShips directly from Japan via tracked airmail. Processing 2–6 business days. Every Tsujimoto Market product is sourced in Japan and verified for authenticity — we never sell fakes or grey-market goods.\u003c\/p\u003e\n\n\u003ch3\u003eFAQ\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is this different from a regular anti-aging serum?\u003c\/strong\u003e\u003cbr\u003eA: It is a quasi-drug (医薬部外品) — a regulatory category between cosmetics and pharmaceuticals in Japan. It has been clinically demonstrated to reduce wrinkle depth, not just smooth their appearance temporarily.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can I use it around the eyes?\u003c\/strong\u003e\u003cbr\u003eA: Yes, on the outer eye area (crow's feet) and under the eye, but avoid direct contact with the eyeball. Apply a tiny amount and pat gently.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: When will I see results?\u003c\/strong\u003e\u003cbr\u003eA: POLA's clinical data shows visible wrinkle improvement after 8 weeks of twice-daily use. Many users continue improvement through 12–24 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can I use it with retinol or vitamin C?\u003c\/strong\u003e\u003cbr\u003eA: Yes. It layers under most routines. If you have very sensitive skin, introduce one new active at a time.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is this the authentic Japanese version?\u003c\/strong\u003e\u003cbr\u003eA: Yes. We ship the Japan domestic SKU directly from Kobe with full tracking.\u003c\/p\u003e\n","brand":"POLA","offers":[{"title":"Default Title","offer_id":46917616435375,"sku":"WrinkleShotN 20","price":18800.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0597\/7561\/5151\/files\/1_4c4d20f2-a2b5-4987-8631-b06e1c2947ad.png?v=1778842303","url":"https:\/\/tsujimotomarket.com\/products\/pola-wrinkle-shot-medical-serum-n-20g","provider":"Tsujimoto Market","version":"1.0","type":"link"}