Tsujimoto Market: Our Guarantees
Description
POLA Wrinkle Shot Medical Serum N — Japan's First MHLW-Approved Anti-Wrinkle Serum
POLA Wrinkle Shot Medical Serum N is the renewed flagship of POLA's prestige anti-aging line. It is a quasi-drug (医薬部外品), meaning it carries Japan's Ministry of Health, Labour and Welfare (MHLW) authorization for the claim "improves wrinkles" — POLA was the first brand in Japan to receive this approval. The active ingredient NEI-L1 is a proprietary triple complex that targets the cellular processes behind deep wrinkles.
The serum has a rich, balm-like texture that melts into skin and is designed for spot-application on wrinkle-prone zones (forehead, eye corners, nasolabial folds, mouth corners). 20g lasts about 4 months with daily morning and evening use.
Key Benefits
- MHLW-approved wrinkle improvement — Japan's first quasi-drug serum certified to reduce visible wrinkles, not just hydrate.
- NEI-L1 active complex — POLA's proprietary triple ingredient targeting the wrinkle-formation pathway in the skin.
- Concentrated balm-melt texture — sits exactly where you place it, no migration into eyes.
- Spot-application format — economical, focuses the active where you need it.
- Prestige Japanese authenticity — sourced directly from Japan, the renewed 2026 N formulation.
How to Use
- Use morning and evening, after toner and serum, before moisturizer.
- Dispense a rice-grain amount onto a fingertip.
- Apply directly onto wrinkles (forehead lines, crow's feet, nasolabial folds, mouth corners). Do not rub into surrounding skin.
- Continue with your regular moisturizer or eye cream over the top.
- Visible change typically appears after 8–12 weeks of consistent use.
Best For
Women in their late 30s through 60s who already use a moisturizer and want to specifically target visible wrinkles — crow's feet, frown lines, nasolabial folds, marionette lines. Pairs well with any base routine.
Ingredients (highlights)
NEI-L1 (proprietary triple complex — primary wrinkle-improvement active), glycerin, dimethicone, ceramide-NP, niacinamide-supporting peptides. Refer to the package for the full INCI list. Free of mineral oil and synthetic fragrance.
Cautions
- For external use only. Avoid direct contact with eyes — if the serum enters eyes, rinse immediately with water.
- Apply a small amount first if you have sensitive skin and observe for 24 hours before regular use.
- Discontinue use if redness, itching or stinging occurs.
- Do not use on broken, sunburnt or actively irritated skin.
- Store at room temperature, away from direct sunlight.
Shipping & Authenticity
Ships directly from Japan via tracked airmail. Processing 2–6 business days. Every Tsujimoto Market product is sourced in Japan and verified for authenticity — we never sell fakes or grey-market goods.
FAQ
Q: How is this different from a regular anti-aging serum?
A: It is a quasi-drug (医薬部外品) — a regulatory category between cosmetics and pharmaceuticals in Japan. It has been clinically demonstrated to reduce wrinkle depth, not just smooth their appearance temporarily.
Q: Can I use it around the eyes?
A: Yes, on the outer eye area (crow's feet) and under the eye, but avoid direct contact with the eyeball. Apply a tiny amount and pat gently.
Q: When will I see results?
A: POLA's clinical data shows visible wrinkle improvement after 8 weeks of twice-daily use. Many users continue improvement through 12–24 weeks.
Q: Can I use it with retinol or vitamin C?
A: Yes. It layers under most routines. If you have very sensitive skin, introduce one new active at a time.
Q: Is this the authentic Japanese version?
A: Yes. We ship the Japan domestic SKU directly from Kobe with full tracking.
