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Japanese OTC eye drops cannot be shipped outside Japan due to regulations. See these alternatives with worldwide delivery:
Description
Santen Sante FX Neo — Cooling Japanese Eye Drops, 6 Active Ingredients, 12 ml
Overview
Santen's strongly cooling eye drop, built for eye fatigue and redness. Six active ingredients — a focus-adjusting agent, two nutrient-supply ingredients, a decongestant, an antihistamine and an anti-inflammatory — sit behind a cooling sensation that comes from d-borneol, dl-camphor and l-menthol in the inactive base. A Class 2 designated OTC medicine in Japan, 12 ml.
See also Japanese eye drops and eye patches.
Key Benefits
- ✓ 6 active ingredients declared by Santen Pharmaceutical, listed in full with their amounts and stated actions below
- ✓ Approved in Japan for eye fatigue, redness, itching, blepharitis and light-induced eye inflammation — the full approved list is printed below rather than paraphrased
- ✓ Relieves the strain of long screen sessions, reading and driving, which is what the focus-adjusting ingredient is there for
- ✓ Usable with hard contact lenses in — discomfort during hard lens wear is itself a listed indication
- ✓ Strong cooling sensation from d-borneol, dl-camphor and l-menthol
- ✓ 12 ml bottle, a Class 2 designated OTC medicine in Japan
- ✓ Authentic Japanese product, packed and dispatched from Kobe with full tracking
Product Details
| Brand | Santen |
|---|---|
| Country of origin | Japan |
| Product type | Eye drops (ophthalmic solution) |
| Format | Sterile eye drop solution |
| Volume | 12 ml |
| Active ingredients | 6 |
| Preservative | Benzalkonium chloride |
| Vendor / Maker | Santen Pharmaceutical |
| Regulatory class | Class 2 designated OTC medicine (Japan) |
| Contact lenses | Hard lenses: may stay in. Soft lenses: remove, do not use. |
Who Is This For?
- Anyone whose eyes are tired at the end of a screen day — the focus-adjusting ingredient is aimed at exactly that.
- Students, drivers and readers who need a drop that works on strain rather than dryness alone.
- Hard contact lens wearers, for whom discomfort during wear is a listed indication.
- People who specifically want a strong cooling sensation rather than a mild one.
- Not for soft contact lens wearers while lenses are in, and not for anyone under treatment for glaucoma without asking their doctor first.
How to Use
- Tilt your head back and gently pull down the lower eyelid.
- Instil 2 to 3 drops into each eye.
- Blink gently to spread the drops.
- Do not let the tip of the bottle touch your eye, eyelid or lashes.
- Close the bottle firmly after use and store it away from direct sunlight and heat.
Frequency: 5 to 6 times a day
Full Ingredients
| Active ingredient | Amount per 100 ml | Action |
|---|---|---|
| Neostigmine methylsulfate | 0.005% | improves the eye's focus adjustment |
| Taurine | 1.0% | promotes metabolism in eye tissue |
| L-Aspartic acid potassium | 1.0% | supports tissue respiration |
| Tetrahydrozoline hydrochloride | 0.05% | constricts conjunctival vessels, clearing redness |
| Chlorpheniramine maleate | 0.03% | blocks histamine, reducing itching |
| Epsilon-aminocaproic acid | 1.0% | suppresses production of inflammatory substances |
Inactive ingredients: Chlorobutanol, benzalkonium chloride, boric acid, d-borneol, dl-camphor, l-menthol, pH adjusters. The cooling sensation comes from the last three; the benzalkonium chloride is the preservative, and it is the reason this one must not be used with soft contact lenses in.
Approved indications: Eye fatigue; eye haziness (when discharge is heavy); conjunctival redness; eye itching; blepharitis (sore eyelids); prevention of eye disease (after swimming, or when dust or sweat gets into the eye); inflammation of the eye caused by ultraviolet or other light (such as snow blindness); discomfort while wearing hard contact lenses.
Cautions
- For ophthalmic use only. This is a medicine — use it for the indications listed above and nothing else.
- Consult a doctor or pharmacist before use if you are under medical treatment, have had an allergic reaction to a medicine, have severe eye pain, or have been diagnosed with glaucoma.
- Stop use and seek advice if you develop a rash, redness or itching of the skin, or congestion, itching, swelling or stinging of the eye.
- Stop use and seek advice if haziness does not improve, or if there is no improvement after 5–6 days.
- Overuse can cause abnormal glare or, paradoxically, more redness than you started with.
- Do not touch the bottle tip to the eye, eyelid or lashes; do not use the solution if it has become cloudy or changed colour.
- Do not share the bottle with anyone else, and do not decant it into another container.
- Children should use it only under adult supervision. Keep out of reach of children.
- Store closed, out of direct sunlight, in a cool place. Do not leave it above 40 °C — a car interior or near a heater will do that.
- Do not use past the expiry date printed on the base of the carton, and finish an opened bottle promptly.
Package Contents
1 × Santen Sante FX Neo eye drops, 12 ml, in its original Japanese carton with the manufacturer's package insert. Santen Pharmaceutical, Japan.
Shipping & Store Notes
- Ships directly from Japan
- Processing time: 2–6 business days
- Tracking number provided after dispatch
- Import duties and taxes may apply depending on destination country
- Opened eye drops cannot be returned for hygiene and safety reasons
- Japanese Class 2 OTC medicines are subject to import restrictions in many countries — please check your destination's rules before ordering
Authenticity Guarantee
Every product at Tsujimoto Market is sourced directly from Japan and verified for authenticity. We never sell fakes or grey-market goods. Each order is carefully packed in Kobe, Japan and dispatched with full tracking.
FAQ
How many drops, and how often?
Two to three drops each time, 5 to 6 times a day. That is Santen Pharmaceutical's own instruction; more than that is not better and can cause glare or rebound redness.
Can I use it with contact lenses in?
Do not use while wearing soft contact lenses — this formula contains benzalkonium chloride, which soft lenses absorb. Discomfort during hard contact lens wear is one of the listed indications, so hard lenses may stay in.
How many active ingredients does it actually have?
Santen Pharmaceutical declares 6, and all 6 are listed above with their amounts per 100 ml and the action Santen Pharmaceutical attributes to each.
Does it contain a preservative?
Yes — benzalkonium chloride. That is standard for this category, and it is the specific reason the drops must not be used with soft contact lenses in, since soft lenses absorb it.
Is this the authentic Japanese product?
Yes. We source directly from Japan and dispatch every order from our warehouse in Kobe with full tracking. Note that this is a Class 2 designated OTC medicine in Japan; many countries restrict the import of foreign OTC medicines, so please check your destination's rules before ordering.

